Knock outs à la pelle

Theoretical knock-outs on biological networks.

In this work we redefine the concept of biological importance and how to compute it, based on a model of complex networks and random walk. We call this new procedure, theoretical knock-out (KO). The proposed method generalizes the procedure presented in a recent study about Oral Tolerance. To devise this method, we make two approaches: algebraically and algorithmically. In both cases we compute...

Contribution à l'étude de la maladie athéromateuse

Médecine à la Molière.

Of Moliere's thirty six plays, seven deal, to a greater or lesser extent, with medicine; the medicine as practiced in Paris during the reign of Louis XIV. In these days, Moliere satirises the recalcitrant conservatism of the Paris medical faculty. It is, however, an informed satirisation. This paper explores Moliere's motives and attempts to place Moliere's medical plays against a broad canvas ...

Death à la carte

Delegates arrived at the hotel on a rainy Sunday evening where they were immediately made welcome and encouraged to relax over dinner while chatting to other EWCD (European Workshop on Cell Death) participants. The EWCD is a bi-annual conference that focuses on all aspects of cell death. Each conference is held in a different unique location, with this year’s being no exception. The six-day mee...

Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs".

The identification of over 500 protein kinases encoded by the human genome sequence offers one measure of the importance of protein kinase networks in cell biology. High throughput technologies for inactivating genes are producing an awe-inspiring amount of data on the cellular and organismal effects of reducing the levels of individual protein kinases. Despite these technical advances, our und...